protein
| associating with the anaphase promoting complex (APC), thereby inhibiting its ubiquitin ligase activity |
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REV3, ADAM9 (MDC9) |
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interaction partner for ELK1 (MAD2L2 acts to promote ELK1 phosphorylation by the c-Jun N-terminal protein kinase (JNK) MAP kinases) (Zhang 2007) |
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YY1AP1-interacting protein, is MAD2L2 |
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interacts with TCF7L2 (is a TCF7L2-binding protein, and interaction abolished the DNA binding ability of TCF7L2) (Hong 2009) |
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RAN is a novel MAD2L2 binding protein (protein-protein interaction may play a role in the control over the spindle checkpoint during mitosis andin the regulation of nucleocytoplasmic trafficking during interphase |
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modulates expression of SNAI2, a TCF4-beta-catenin-inducible gene, and E-cadherin, a downstream target gene of SNAI2 (Hong 2009) |
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interacts with CLTA during the G2/M phase of the cell cycle and depletion of MAD2l2 leads to a marked increase in the percentage of misaligned chromosomes and a redistribution of CLTA during mitosis (pMID: 21152103) |
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MAD2L2 is a novel SIM2 binding protein |
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role of MAD2L2 in governing REV1 stability and interplay between translesion DNA synthesis (TLS) and anaphase-promoting complex (APC)-dependent proteolysis |
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MAD2L2 helps to ensure a robustly bistable switch between APC/C(CDC20) and APC/C(CDH1) during the metaphase-to-anaphase transition, thereby contributing to mitotic fidelity |
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MAD2L2 has a profibrotic role during fibroblast activation and tubulointerstitial fibrosis (TIF) by suppressing SKIL expression |
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stabilize and enhance the polymerase activity of the catalytic subunit, REV3L |
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MAD2L2 promotes open chromatin in embryonic stem cells and derepresses the DPPA3 Locus |