SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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text
| levels of TTK are relatively low in cells during interphase but elevated in mitosis or upon activation of the spindle checkpoint |
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localize to both centrosomes and kinetochores |
basic FUNCTION
| functioning at the mitotic spindle checkpoint |
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required for progression of mitosis |
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essential for the mitotic checkpoint, and also controls correction of improper chromosome attachments |
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coordinating attachment error correction and checkpoint signaling, two crucial responses to unproductive chromosome attachments |
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crucial for the spindle assembly checkpoint and for chromosome biorientation on the mitotic spindle |
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required for the correction of improper chromosome-microtubule attachments |
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having a function in procentriole assembly |
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is required for spindle checkpoint activation |
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critical kinase, and its activity is required for both normal chromosome alignment and for regulating the spindle checkpoint |
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its kinase activity is required for proper chromosome segregation during mitosis through its involvements in microtubule-chromosome attachment error correction and the mitotic checkpoint |
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release of TTK from kinetochores is essential for mitotic checkpoint silencing and a fast metaphase-to-anaphase transition |
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TTK-dependent phosphorylation of CETN2 stimulates the canonical centriole assembly pathway) |
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may participate in cytokinesis via the regulation of SPECC1L |
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conserved protein kinase critical for spindle pole body (the functional equivalent of the centrosome) duplication, spindle checkpoint, kinetochore biorientation, and chromosome-microtubule attachment |
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but what role it plays in SPECC1L function remains to be discovered |
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novel role for AURKB-NDC80-TTK signaling axis in governing accurate chromosome segregation in mitosis |
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is a mitotic checkpoint kinase responsible for sensing the unattached and tensionless kinetochore |