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FLASH GENE
Symbol AKR1A1 contributors: - updated : 07-05-2007
HGNC name aldo-keto reductase family 1, member A1 (aldehyde reductase)
HGNC id 380
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 liver   highly
Endocrinethyroid   highly
Nervousbrainforebraincerebral cortex highly
Urinarykidney   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to murine Akr1a4
Homologene
FAMILY aldo-keto reductase (AKR) superfamily
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • aldehyde (aldoketo) reductase 1, monomeric, NADPH dependent, reducing various biogenic and xenobiotic aldehyde compounds
  • playing an important role in detoxification of arising reactive metabolites during cell proliferation and tissues development
  • NADPH-dependent oxidoreductase involved in catalyzing the reduction of aldehydes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH
    protein binding ZNF143 or DDIT3
    cell & other
    REGULATION
    Other regulated by ZNF143 and DDIT3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to non-Hodgkin lymphoma (NHL)
    Variant & Polymorphism SNP significantly associated with an increased overall risk of NHL
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS