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FLASH GENE
Symbol GDF3 contributors: mct - updated : 15/10/2008
HGNC name growth differentiation factor 3
HGNC id 4218
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
 thymus    
Reproductivemale systemtestis  lowly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell
cell lineage
cell lines human embryonal carcinoma cell lines in a stem cell-specific fashion
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 24 aa signal peptide
  • TGF beta-like domain
  • TGF beta propeptide (LAP)
  • conjugated GlycoP
    mono polymer homomer , heteromer , dimer
    isoforms Precursor cleaved at a consensus Arg-X-XArg to yield a C terminus mature dimer
    HOMOLOGY
    interspecies homolog to rattus Gdf3 (68.9 pc)
    homolog to murine Gdf3 (71.2 pc)
    Homologene
    FAMILY
  • TGF-beta family
  • BMP (bone morphogenetic protein) family
  • CATEGORY signaling cytokine growth factor
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • playing a role in the regulation of adult lymphatic and erythroid systems
  • regulating the ability to maintain the undifferentiated state and the ability to differentiate into the full spectrum of cell types of embryonic stem cells
  • functional complementarity between GDF1 and GDF3 during embryonic development
  • important and evolutionarily conserved role for GDF3 in oculo-skeletal development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CRIPTO (CRIPTO acts as an obligate coreceptor for transforming growth factor beta (TGF-beta) ligands, including nodals, growth and differentiation factor 1 (GDF1, and GDF3)
  • cell & other
    REGULATION
    activated by cleaved by subtilisin like convertases
    ASSOCIATED DISORDERS
    corresponding disease(s) KFS3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS