basic FUNCTION
| photoreceptor cell-specific nuclear receptor, involved in determining photoreceptor phenotype during retinogenesis |
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involved in regulating and maintaining the expression of rod photoreceptor-specific genes and may be in transcriptional regulatory network(s) during rod differentiation |
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dual-function transcriptional regulator acting in concert with CRX to promote and maintain the function of rod photoreceptors |
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functioning either directly or indirectly, as a repressor of cone-specific genes in rod photoreceptor cells |
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playing a critical role in establishing functional specificity of neural retina leucine zipper expressing photoreceptor precursors during retinal neurogenesis |
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acting as a negative regulator for cell proliferation of retina neurons |
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playing a key role in the regulation of photoreceptor-specific genes during rod development and maintenance |
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a pivotal role in the differentiation of photoreceptors |
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in postmitotic rods, influences rod cell differentiation, whereas, in late mitotic progenitors, its primary function is to suppress the cone-generation program |
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acting simultaneously in different cell types: in late mitotic progenitors, newly differentiating post mitotic cells, and mature rods and cones |
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photoreceptor-specific nuclear receptor believed to play a role in photoreceptor development, differentiation, and survival |
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dual role in specification of photoreceptor fate during development as well as photoreceptor maintenance in the adult |
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influence the competency of retinal progenitors while simultaneously directing the rod and cone differentiation |
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represses cone-specific genes and activates several rod-specific genes |
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a potential role for NR1D1, in conjunction with its cofactor NR2E3, in regulating transcriptional networks critical for photoreceptor development and function |