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FLASH GENE
Symbol MAP2K6 contributors: SGE/npt - updated : 14-09-2018
HGNC name mitogen-activated protein kinase kinase 6
HGNC id 6846
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a docking site, a stretch of about 20 amino acids immediately on the C-terminal side of the MAPKK catalytic domain (Takekawa 2005)
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Map2k6
    homolog to C.elegans R03g5.2
    intraspecies homolog to MAP2K3
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • MAP kinase kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • serine/threonine kinase, controlling cell proliferation (cell cycle arrest)
  • involved in TNFA mediated endothelial SCYA2 (MCP1) expression
  • involved in BMP4-stimulated osteocalcin synthesis, as a positive regulator in osteoblasts
  • activating PRKMK8 and p38 kinase (MAPK) and required for ABL1 induced apoptosis
  • downregulates NADPH oxidase activity by enhancing Rac-GTPase activity (Harraz 2007)
  • with MAP3K7, constitute the p38 signalling pathway to participate to Osteoclasts differentiation by TNFSF11 through p65 phosphorylation and NFATC1 induction (Huang 2006)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p38-dependent mRNA stabilization of 42 AU rich genes, some involved in macrophage activation
  • inducing SOCS3
  • stress activated kinase MAP2K6 acts as a repressor of UCP1 expression, suggesting that its inhibition promotes adipose tissue browning and increases organismal energy expenditure
  • cell & other
    REGULATION
    activated by UV, anisomycin and os miotic stock
    phosphorylation
    TNFA
    Other phosphorylated by MAP3K5 (Sturchler 2010)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS