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FLASH GENE
Symbol SLC4A7 contributors: mct - updated : 20-08-2015
HGNC name solute carrier family 4, sodium bicarbonate cotransporter, member 7
HGNC id 11033
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon   Homo sapiens
 intestinelarge intestinerectum   Homo sapiens
 salivary glandparotid  highly Homo sapiens
Hearing/Equilibriumearinnercochlea  
Reproductivemale systemprostate  highly
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Hearing / Equilibriumstereocilia
Visualcone photoreceptor
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve membrane spanning domains protein with intracellular N and C termini
  • a PDZ-binding motif mediating interaction with the CFTR, SLC9A3R1 complex and probably with USH1C
  • HOMOLOGY
    interspecies homolog to rattus Slc4a7 (93.8pc)
    homolog to murine Slc4a7 (94.6pc)
    Homologene
    FAMILY
  • solute carrier family 4, chloride-bicarbonate
  • anion exchanger family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    text
  • USH2A, MASS1 and SLC4A7 are co-expressed with the USH1-protein harmonin in the synaptic terminals of both retinal photoreceptors and inner ear hair cells
  • localizes in mitochondria and suppresses the ischaemia-induced activation of the mitochondrial pathway of apoptosis in coronary endothelial cells
  • basic FUNCTION
  • may play a role in bicarbonate salvage in secretory epithelia
  • may also have an associated sodium channel activity
  • stable association of SLC4A7 at the membrane may facilitate constitutive uptake of HCO(3)(-) across the basolateral membrane (BLM)
  • in the kidney medullary thick ascending limb cell line is upregulated under acidic conditions and enhances ammonium transport
  • is electroneutral because it has an apparent stoichiometry of 1:1
  • plays an essential role in intracellular pH regulation and transepithelial HCO(3)(-) movement in the body
  • plays a critical role in pHi regulation in colonic epithelial cells
  • catalyzes the electroneutral movement of 1 Na(+):1 HCO3(-) into kidney cells
  • plays a role in transepithelial HCO3 (-) movement and intracellular pH maintenance in many tissues
  • plays a role in neutralizing intracellular acid loads at the basolateral membrane in cells of the medullary thick ascending limb (mTAL)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the postsynaptic density protein DLG4 in the brain, and DLG4 increases its channel-like activity while negligibly affecting Na/HCO(3) cotransport
  • physically and functionally associated with a variety of membrane and cytosolic proteins via the binding partners
  • binds to many PDZ proteins, which in turn may allow the transporter to associate with other physiologically important proteins
  • cell & other
    REGULATION
    Other regulated by CFTR (Park 2002)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility may be potential causative gene for breast cancer (Ahmed 2009)
    Variant & Polymorphism SNP allelic variants might alter disposition and/or excretion of drugs and neurotransmitters in brain and periphery in ways that could contribute to differential vulnerabilities to addictions (Ishiguro 2007)
    Candidate gene
  • for USH2B
  • for the contribution to vulnerability to addictions (Ishiguro 2007)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS