basic FUNCTION
| plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin |
|
functions as a determinant of membrane potential and regulator of cell fusion in physiologic skin progenitor cells |
|
responsible for the resistance to doxorubicin of a subset of malignant melanomas |
|
full-sized ABC transporter that confers anticancer drug resistance |
|
acts as an energy-dependent drug efflux transporter and marks tumour cells of a putative cancer stem cell (CSC) compartment |
|
its expression is closely linked to tumorigenicity and progression of diverse human malignancies, including melanoma, and is functionally required for tumor growth |
|
plays a key role in melanoma growth, and is a novel pro-metastasis factor |
|
is a critical determinant of Colorectal cancer invasiveness |