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FLASH GENE
Symbol IL32 contributors: mct - updated : 13-05-2008
HGNC name interleukin 32
HGNC id 16830
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveesophagus   highly
 stomach   highly
Urinarykidney   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immuneactivated B lymphocyte
cell lineage
cell lines
fluid/secretion secreted protein
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three potential N-myristoylation sites
  • one N-glycosylation site
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • potentially involved in cell adhesion
  • may play a role in lymphocyte activation
  • inducing the production of TNFalpha from macrophage cells
  • playing a role in the pathophysiology of clonal myeloid diseases
  • not only contributes to host responses through the induction of proinflammatory cytokines but also directly affects specific immunity by differentiating monocytes into macrophage-like cells
  • may be playing a role in inflammatory bowel diseases
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in rheumatoid arthritis synovial tissue
    tumoral     --other  
    dysregulation in myelodysplastic syndrome (MDS) and myeloproliferative disorder
    Susceptibility to rheumatoid arthritis
    Variant & Polymorphism SNP
    Candidate gene
    Marker
    Therapy target therapeutic targets for patients with myelodysplastic syndrome (MDS) and myeloproliferative disorder
    ANIMAL & CELL MODELS