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FLASH GENE
Symbol TTC4 contributors: mct - updated : 21-09-2016
HGNC name tetratricopeptide repeat domain 4
HGNC id 12394
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three tetratricopeptide motif
  • a coiled-coil domain outside the TPR domain towards the C terminus
  • HOMOLOGY
    interspecies homolog to C.elegans c17g10.2
    homolog to Drosophila Dpit47
    Homologene
    FAMILY
  • TTC4 family
  • CATEGORY motor/contractile , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • localizes to the cytoplasm, but co-expression with a known protein interaction partner, hampin/MSL1, results in the nuclear translocation of the TTC4 protein
  • basic FUNCTION
  • is a putative tumor suppressor involved in the transformation of melanocytes 5)
  • is an HSP90AA1 co-chaperone protein which forms a link between HSP90 chaperone activity and DNA replication
  • nuclear transport of TTC4 is apparently a complex process dependent on interactions with other proteins during the progression of the cell cycle, and nuclear accumulation of TTC4 might be a potential link with regard to its function in tumor suppression
  • critical for cilia formation and function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • nucleoplasmic protein which interacts with HSP90AA1 and HSPA4, and also with the replication protein CDC6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in malignant melanoma
    tumoral   deletion    
    in sporadic breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS