basic FUNCTION
| encoding an MLH1 interactor |
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acting as a tumor suppressor involved in genetic stability and participating in DNA damage checkpoint |
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important roles in maintaining genome stability through base excision repair (BER) processes and mismatch repair (MMR) processes |
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wide role for MBD4 in DNA damage response and maintaining chromosomal stability |
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efficiently processed T/G mismatches within the nucleosome |
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excises thymine from mutagenic G·T mispairs generated by deamination of 5-methylcytosine, and downstream base excision repair proteins restore a G·C pair |
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provides selective interactions with the mismatched guanine (N1H, N2H(2)) that are not compatible with adenine, which likely confer mismatch specificity |
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is upregulated at the protein level upon oxidative stress, and is essential for cell survival following oxidative stress |
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is likely a component of mismatch repair (MMR)-directed DNA end processing |
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is also involved in DNA damage response and transcriptional regulation |
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MBD4 excises thymine from G·T mispairs, suppressing mutations caused by deamination of 5-methylcytosine, and it removes uracil and modified uracils (e.g., 5-hydroxymethyluracil) mispaired with guanine |
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encodes a glycosylase involved in repair of G:T mismatches resulting from deamination of 5& |
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8242;-methylcytosine |