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FLASH GENE
Symbol SLPI contributors: mct/npt/pgu - updated : 29-11-2017
HGNC name secretory leukocyte protease inhibitor (antileukoproteinase)
HGNC id 11092
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly Homo sapiens
 salivary gland   highly Homo sapiens
Respiratoryrespiratory tracttrachea  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmoothmyoepithelium highly
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion secreted by epithelial cells in all the mucosal fluids such as saliva, cervical mucus, as well in the seminal liquid, bronchial secretions
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two acid stable polypeptide functional domains (thypsin inhibitory site
  • elastase inhibitory site)
  • two WAP type domains, WAP domains playing pivotal roles in the antimicrobial and/or antiprotease activities and their application in therapeutics are expected to have practical value
  • secondary structure eight disulfide bonds
    HOMOLOGY
    interspecies homolog to murine Slpi
    homolog to C.elegans c45g7.3
    Homologene
    FAMILY
  • WAP-type "four-disulfide core" domain proteins family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    text
  • secreted by epithelial cells in all the mucosal fluids such as saliva, cervical mucus, as well in the seminal liquid
  • predominantly localized in the nuclei of myocytes and colocalized with CD68(+) macrophages
  • basic FUNCTION
  • secretory leukoprotease inhibitor
  • involved in antineutrophil elastase protection at inflammatory sites
  • protecting epithelial tissues from serine proteases
  • prominent innate immune protein of the respiratory tract, possessing serine protease inhibitor activity, antibacterial activity, and anti-inflammatory/immunomodulatory activity
  • can inhibit interferon-gamma-induced cathepsin S production by macrophages
  • cationic non-glycosylated antiprotease synthesized and secreted by cells at the site of inflammation
  • able to disrupt the association between PLSCR1 and CD4, suggesting that SLPI inhibits HIV-1 infection by modulating the interaction of the CD4 receptor with PLSCRs
  • constitutive expression of PI3 and SLPI in cervical cells during pregnancy suggests their essential roles in local tissue homeostasis and immune defense
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for the phospholipid scramblase 1 (PLSCR1) and PLSCR4, membrane proteins that are involved in the regulation of the movements of phospholipids between the inner and outer leaflets of the plasma membrane
  • MMP12 is a PGRN proteolytic enzyme, and SLPI an inhibitor of MMP12-induced PGRN proteolysis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly decreased in prostate cancers compared with that in benign prostate epithelial cells
    constitutional     --over  
    expressed in myometrium and increased after the onset of labor
    Susceptibility
    Variant & Polymorphism
    Candidate gene for lipodystrophy and diabetes
    Marker
    Therapy target
  • may constitute new targets for antiviral intervention
  • therapeutically important as a potential inhibitor of protease expression in chronic obstructive pulmonary disease
  • ANIMAL & CELL MODELS