basic FUNCTION
| secretory leukoprotease inhibitor |
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involved in antineutrophil elastase protection at inflammatory sites |
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protecting epithelial tissues from serine proteases |
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prominent innate immune protein of the respiratory tract, possessing serine protease inhibitor activity, antibacterial activity, and anti-inflammatory/immunomodulatory activity |
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can inhibit interferon-gamma-induced cathepsin S production by macrophages |
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cationic non-glycosylated antiprotease synthesized and secreted by cells at the site of inflammation |
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able to disrupt the association between PLSCR1 and CD4, suggesting that SLPI inhibits HIV-1 infection by modulating the interaction of the CD4 receptor with PLSCRs |
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constitutive expression of PI3 and SLPI in cervical cells during pregnancy suggests their essential roles in local tissue homeostasis and immune defense |