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FLASH GENE
Symbol GLP2R contributors: mct - updated : 25-08-2011
HGNC name glucagon-like peptide 2 receptor
HGNC id 4325
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor, secretin family, coupling with Gs alpha protein and activating adenylate cyclase
  • C terminus is not required for coupling to cellular machinery regulating signaling or desensitization, but it may serve as a sorting signal for intracellular trafficking
  • HOMOLOGY
    interspecies homolog to murine Gpl2r
    Homologene
    FAMILY
  • Family B glucagon-secretin GPCR family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • stimulating growth and proliferation of intestinal cells
  • its signaling has evolved unique structural and functional mechanisms for control of receptor trafficking, desensitization, and resensitization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by G proteins activating adenyl -cyclase
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • elimination of GLP-2R signaling in obese mice impairs the normal islet adaptive response required to maintain glucose homeostasis