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FLASH GENE
Symbol HUS1 contributors: mct/npt/pgu - updated : 28-01-2009
HGNC name HUS1 checkpoint homolog (S. pombe)
HGNC id 5309
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunespleen   highly
Reproductivemale systemtestis  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , trimer
HOMOLOGY
interspecies homolog to yeast S.pombe Hos1
homolog to murine Hus1
Homologene
FAMILY
  • HUS1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in cell cycle G2 checkpoint control
  • involved in DNA damage checkpoint regulation, which is required for the maintenance of genomic stability
  • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    text DNA damage checkpoint
    PATHWAY
    metabolism
    signaling
    a component
  • forming DNA damage-responsive protein complex with RAD1 and RAD9A, heterotrimeric complex (Rad9A-Rad1-Hus1 cell cycle checkpoint complex plays a key role in the DNA damage response
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with itself and the C terminus of RAD1
  • interacting with TDG
  • interacting with COPS5 (mediates protein degradation of the Rad9A-Rad1-Hus1 checkpoint complex)
  • DNA2 shows partial redundancy for the replication checkpoint with checkpoint initiators RAD9-RAD1-HUS1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    sensitizes cells to etoposide-induced apoptosis not only by inducing BCL2L11 and BBC3 expressions but also by releasing RAD9A into the cytosol to augment mitochondrial apoptosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene prognostic markers in epithelial ovarian tumors
    Marker
    Therapy target
    ANIMAL & CELL MODELS