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FLASH GENE
Symbol MOCS2 contributors: mct - updated : 04-05-2016
HGNC name molybdenum cofactor synthesis 2
HGNC id 7193
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Digestivesalivary gland   highly
Endocrinepancreas    
 parathyroid   highly
Nervousbrain    
Respiratoryrespiratory tracttrachea  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a highly conserved C-terminal double glycine motif, and extension of the C terminus with an additional glycine of MOCS2 and URM1 altered the localization of MOCS3 from the cytosol to the nucleus
  • first step of activation of both MOCS2 and URM1 consists of the formation of an acyl-adenylate group at the C-terminal glycine residue
  • mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • moaE family
  • MOCS2B subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • dual localization in the cytoplasm and the nucleus
  • basic FUNCTION
  • bicistronic enzyme, catalyzing the second step of the molybdenum cofactor synthesis
  • converting precursor Z (see MOCS1) to molybdopterine
  • essential for the function of sulphite oxidase, xanthine dehydrogenase, and aldehyde oxidase enzymes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    molybdenum cofactor biosynthesis
    a component
  • heterodimer of a large and a small subunit
  • MOCS3 forms heterotetrameric complexes with both URM1 and MOCS2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with both URM1 and MOCS2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MOCODB
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS