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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

TNK1

contributors: - updated : 12-06-2007

HGNC name	tyrosine kinase, non-receptor, 1
HGNC id	11940

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       mouth       highly Reproductive female system uterus     highly   male system testis         male system prostate     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal kinase domain
	a putative SH3 domain
	a ferm domain
	a proline-rich C terminal region

HOMOLOGY

Homologene

FAMILY

Ack family of NRPTKs

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	intracellular tyrosine kinase playing a potential role in oncogenic transformations resulting in increased kinase activity
	playing a role in phospholipid signal transduction
	playing a negative regulatory role in regulating the Ras-RAF1/MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to late-onset Alzheimer's disease

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS