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FLASH GENE
Symbol RGS9 contributors: mct/npt - updated : 09-03-2016
HGNC name regulator of G-protein signalling 9
HGNC id 10004
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainbasal nucleicaudate nucleus highly
nervousbrainbasal nucleiputamen highly
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensoryvisualphotoreceptor layer 
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
Visualcone photoreceptor
Visualrod photoreceptor
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal DEP (dishevelled/Egl10/pleckstrin) homology domain
  • a GGL domain forming complex with GNB5
  • a RGS homology domain directly responsible for accelerating the GTPase activity of G protein alpha-subunits (Martemyanov 2008)
  • a C terminal region highly enriched in proline and serine residues
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans EGL-10
    homolog to yeast SST2
    homolog to C.elegans c16c2.2
    homolog to murine Rgs9
    Homologene
    FAMILY
  • RGS family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text outer segments
    basic FUNCTION
  • functioning as GTPase activating protein for G proteins alpha i and q subunits
  • underlying the dominant recovery time of (mouse) photoreceptor that a precise level of expression of RGS9 is required for normal photoresponse timing
  • controlling PDE activity through regulation of transducin and inhibiting retinal guanylyl-cyclase
  • RGS9 and SLC24A1 are active in phototransduction in rods and cones
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
  • heterodimer with G beta 5
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • G (t)-alpha
  • G beta5
  • R9AP (anchor protein of RGS9)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PERRS
    Susceptibility to antipsychotic-induced tardive dyskinesia in schizophrenia
    Variant & Polymorphism other a significant association of the AGG haplotype (rs8077696-rs8070231-rs2292593) with antipsychotic-induced tardive dyskinesia in schizophrenia (Liou 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    expression diminished in the amphetamine-treated animal model of schizophrenia and in post-mortem schizophrenia brain