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FLASH GENE
Symbol KMO contributors: - updated : 25-05-2005
HGNC name kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
HGNC id 6381
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY G-protein coupled receptor 1 family, opsin subfamily
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
basic FUNCTION
  • NADPH-dependent flavin monooxygenase catalyzing the hydroxylation of the L-tryptophan metabolite L-kynurenine to form L-3-hydroxykynurenine
  • may play a role in encephalic photoreception
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene therapeutic target for Huntington disease
    Marker
    Therapy target
    ANIMAL & CELL MODELS