Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --over
|  
|
in lipid rafts observed in the Alzheimer's disease brain | constitutional
|  
| deletion
|  
|  
|
resulted in dysregulation of cell cycle-regulatory genes and blockade of cardiomyocyte proliferation | constitutional
|  
|  
|  
| loss of function
|
disrupts transverse tubule formation, inhibits physiological hypertrophy, and represses fetal-to-adult isoform switching, thus culminating in cardiomyocyte immaturation | constitutional
|  
| deletion
|  
|  
|
deletion of NAE1, the subunit of only E1 enzymes, led to complete failure of myotube formation | tumoral
|  
|  
| --over
|  
|
NAE1 and UBE2M, two critical components of the neddylation pathway, were much higher in Osteosarcoma tissues and cells than in normal osseous tissues and cells | tumoral
|  
|  
| --over
|  
|
in colorectal cancer, the elevated expression of NAE1 correlates with cancer progression and poor prognosis | |