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FLASH GENE
Symbol TNFRSF6B contributors: mct/npt - updated : 15/11/2008
HGNC name tumor necrosis factor receptor superfamily, member 6b, decoy
HGNC id 11921
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
 intestinelarge intestinecolon highly
 stomach   predominantly
Lymphoid/Immunelymph node   highly
Respiratoryrespiratory tractlarynx  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period fetal
Text brain, liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracytoplasmic cysteine-rich pseudorepeats typical for the TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic domain
  • the DEATH domain, soluble form
  • mono polymer homomer , trimer
    HOMOLOGY
    interspecies ortholog to murine Rtel1
    Homologene
    FAMILY
  • tumor necrosis factor receptor (TNFR) superfamily
  • helicase family
  • RAD3/XPD subfamily
  • stathmin family
  • CATEGORY regulatory , protooncogene , receptor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    text type I transmembrane protein (TM1)
    basic FUNCTION
  • required for genome stability and tumor avoidance
  • inhibiting FasL induced apoptosis
  • probable ATP-dependent DNA helicase
  • may be contributing to cell growth and tumor progression
  • involved in both antigen-presenting cell differentiation and lymphocyte function
  • can antagonize homologous recombination at an early stage, after strand invasion, and could promote synthesis-dependent strand annealing
  • CELLULAR PROCESS cell life, differentiation
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    text
  • modulation of dendritic cell differentiation
  • maturation as a soluble receptor Fc protein
  • PATHWAY
    metabolism nucleic
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • Fas ligand (TNFRSF6)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    and/or amplified in primary lung,colon and other gastrointestinal tumors
    constitutional     --over  
    in inflamed intestinal epithelia and is secreted by T lymphocytes isolated from individuals with IBD
    tumoral     --other  
    loss of homologous recombination control after deregulation of TNFRSF6B may be a critical event that drives genome instability and cancer
    tumoral     --over  
    in gastrointestinal tract tumors
    Susceptibility
  • to inflammatory bowel disease (IBD), with pediatric-onset
  • to high-grade glioma susceptibility (Wrensch (2009)
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target may prove potentially to be a valuable target for new anticancer therapeutics
    ANIMAL & CELL MODELS