basic FUNCTION
| inhibits all MMPs |
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erythroid potentiating and cell growth-promoting activities |
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inhibits endothelial cell growth |
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reduces tumor growth when it's overexpressed |
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participates in metanephric mesenchymal growth and in morphogenesis of the ureteric bud |
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antiapoptotic activity |
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with MMP14, control cell proliferation and migration through a non-proteolytic mechanism |
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role for MMP14/TIMP-2 interaction, in controling cell functions by a mechanism independent of extracellular matrix degradation |
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inhibiting ADAM12 and ADAM17 |
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TIMP2 and TIMP3 play fundamental and differential roles in mediating pathological remodelling, independent from their MMP-inhibitory function |
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is a promiscuous MMP inhibitor that is ubiquitously expressed in normal tissues |