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FLASH GENE
Symbol ABCC3 contributors: - updated : 22-03-2005
HGNC name ATP-binding cassette, sub-family C (CFTR/MRP), member 3
HGNC id 54
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 intestinesmall intestine   
 liver    
Reproductivemale systemprostate   
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte
cell lineage
cell lines hepatocellular carcinoma cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two tandemly repeated polytopic membrane-spanning domains (MSDs) typical of ABC transporters, and a third NH(2)-terminal MSD
  • two ATP binding (nucleotide binding fold) each containing highly conserved Walker motifs
  • three transmembrane (3TM) domains (3 x 6 segments)
  • HOMOLOGY
    Homologene
    FAMILY ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 3
    CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text basolateral membrane of cholangiocytes
    basic FUNCTION
  • ABC transporter,traffic ATPase,involved in the adrenal glands
  • biliary and intestinal excretion of organic anions and drugs (methotrexate,etoposide)
  • ATP-dependent transporter of bile salts
  • inducible transporter in the liver,under cholestic conditions
  • may contribute as a plausible bile salt-exporting transporter to the enterohepatic circulation of bile salts
  • having specific biologic functions in epidermal lipid reorganization during terminal keratinocyte differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by chenodeoxycholic acid (CDCA), in a dose- and time-dependent manner
    Other inverse of ABCC2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS