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FLASH GENE

Symbol

LMO7

contributors: mct - updated : 08-01-2020

HGNC name	LIM domain only 7
HGNC id	6646

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus       lowly Cardiovascular heart       highly Digestive intestine large intestine colon   lowly   liver       lowly Endocrine adrenal gland       lowly   pancreas         Hearing/Equilibrium ear inner     lowly Homo sapiens Nervous brain         Reproductive male system testis     lowly   male system prostate     lowly Respiratory lung       highly Homo sapiens Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial         Muscular striatum skeletal     Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	lung,heart

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a calponin homology (CH) domain, a one PDZ domain, a C terminal LIM domain
	an F-Box (FBX) domain is present in alternative splice variants

HOMOLOGY

Homologene

FAMILY

LMO gene family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	specifically localized in the cuticular plate and the cell junction

basic FUNCTION	regulating emerin gene expression
	forming a specific protein-binding interface for protein-protein interactions
	MLLT4- and ACTN1-binding protein that connects the PVRL1-MLLT4 and E-cadherin-catenin systems through alpha-actinin
	regulating development
	possible essential functions for LMO7 during vertebrate heart development
	required for proper myoblast differentiation
	cell-specific regulator of myocardin-related transcription factors (MRTFs) and plays an important role in breast cancer cell migration
	colocalizes with F-actin and reduces the G-actin/F-actin ratio via a Rho-independent mechanism
	LMO7 is dispensable for skeletal muscle and cardiac physiology and pathophysiology
	LMO7 via its LIM domain acts to control mitosis progression and exerts an effect on the SAC
	LMO7 is induced by TGFB1 and serves to limit vascular fibrotic responses through negative feedback regulation of the TGFB1 pathway

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	zinc Zn2+

protein	binding emerin protein, and EDMD-relevant genes
	required for emerin gene transcription
	feedback-regulated by binding to emerin
	bound alpha-actinin, an actin filament-bundling protein, which bound to alpha-catenin
	EMD binds to and inhibits the activity of LMO7, a transcription factor that regulates the expression of genes implicated in EMD (functional interaction between emerin and LMO7 is crucial for temporally regulating the expression of key myogenic differentiation genes)
	interacted with the spindle assembly checkpoint (SAC) protein MAD1L1
	LMO7 and LIMCH1 were identified as interaction partners to LRIG3
	LMO7 and LIMCH1 physically interact with LRIG proteins

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in the stroma of invasive breast carcinoma in a manner that correlates with the increased expression of SRF target genes that regulate muscle and actin cytoskeleton functions

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	deletion of Uchl3 and Lmo7 on mouse chromosome 14 causes defects in viability, postnatal growth and degeneration of muscle and retina
	Lmo7-null mice had growth retardation, decreased fiber size, and impaired skeletal muscle and cardiac function, and loss of Lmo7 in mice causes myopathic phenotypes similar to those seen in other EDMD mouse models