Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CA11 contributors: mct/npt - updated : 16-07-2008
HGNC name carbonic anhydrase XI
HGNC id 1370
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Nervousbrainforebraincerebral cortex highly
 brainhindbraincerebellum moderately
nervousbrainbasal nucleiputamen  
Nervousnerve   highly
 spinal cord   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text neuroprogenitor cells in the subventricular zone as early as the 84th day of gestation and subsequently detected in the neural cells migrating to the cortex
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • missing the three His essential for catalytic activity
  • a sequence homologous to the frog neuropeptide sauvagine
  • conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    intraspecies homolog to acatalytic carbonic anhydrase peptide VIII and X
    Homologene
    FAMILY
  • alpha-carbonic anhydrase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • E3 ligases that target TP53 as well as phospho-TP53 for degradation
  • play roles in various biological process of the CNS
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • target SFN for degradation, leading to MDM2 stabilization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    enhancing MDM2/MDMX interaction
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS