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FLASH GENE
Symbol KCNJ13 contributors: mct - updated : 06-10-2016
HGNC name potassium inwardly-rectifying channel, subfamily J, member 13
HGNC id 6259
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  predominantly
Endocrineadrenal gland   highly
Nervousplexus choroid    
Urinarykidneynephron   
 kidneytubule   
urinarykidneynephrondistal convoluted tubule  
Visualeyeretina  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningretinal pigment epithelium (RPE)   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticfollicular dendritic
Visualcone photoreceptor Homo sapiens
Visualrod photoreceptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two membrane-spanning domains
  • an amphipatic region pore, including the P domain with the K+ channel signature
  • an ATP-binding regulatory domain
  • C-terminal length plays an important role in the plasma-membrane localization of KCNJ13
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY potassium channel subfamily J
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • putatively involved in the functional coupling between the channel and Na+K+ ATPase
  • regulates the transition from quiescence to contractions in the pregnant uterus and may be a target for therapies to control uterine contractility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coupling of MC4R to KCNJ13 may explain unusual aspects of the control of energy homeostasis by melanocortin signalling, including the gene dosage effect of MC4R and the sustained effects of AGRP on food intake
  • cell & other
    REGULATION
    Other dual regulation of KCNJ13 channel function by PRKACA and PRKCA
    ASSOCIATED DISORDERS
    corresponding disease(s) SVD , LCA16
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS