basic FUNCTION
| actin-dependent regulator of chromatin |
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playing a role in chromatin remodeling by mediating the association of cohesin and chromatin |
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may control germline stem cell self-renewal in the ovary |
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involved in multiple nuclear functions, including transcriptional regulation, replication, and chromatin assembly |
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mediate nucleosome assembly and spacing during replication |
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possesses nucleosome-dependent ATPase activity, whereas RSF1 (HBXAP) functions as a histone chaperone |
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both the full-length RSF1 and SMARCA5 were required to form a functional RSF complex responsible for the growth suppression effects |
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BAZ1A and SMARCA5, accumulate rapidly at DNA double-strand breaks and are required for DSB repair |
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evolutionarily conserved nucleosome remodelling factor that regulates gene expression and chromosome organization genome-wide |
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controls chromatin organization and histone H1 dynamics for the establishment of gene expression programs underlying cerebellar morphogenesis and neural maturation |
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SMARCA1, SMARCA5 are ATP-dependent chromatin remodelling proteins that assemble, reposition and space nucleosomes, and are robustly expressed in the brain |
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SMARCA5 targeting to DNA damage-stalled transcription sites is controlled by an ATP-hydrolysis-dependent scanning and proofreading mechanism, highlighting how SWI2/SNF2 chromatin remodelers identify and bind nucleosomes containing damaged DNA |
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SMARCA5 contributes to breast cancer cell proliferation and invasion |
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SMARCA5 and SMARCA1 position nucleosomes adjacent to CTCF and other transcription factors |
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SMARCA4 and SMARCA5 are catalytic subunits of distinct ATP-dependent chromatin remodeling complexes implicated in transcriptional regulation |
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is essential for the establishment of lens vesicle polarity, partitioning of prospective lens epithelial and fiber cell compartments, lens fiber cell differentiation, and lens fiber cell nuclear degradation |
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is one of the most conserved chromatin remodeling factors |
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SMARCA5 plays indispensable roles during early hematopoiesis and erythropoiesis |
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ISWI proteins SMARCA1, SMARCA5 interact with BAZ (bromodomain adjacent to PHD zinc finger) domain containing proteins to generate eight distinct remodeling complexes ( |
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RSF1 is recruited at double strand break (DSB) sites and regulates ataxia telangiectasia mutated (ATM) -dependent checkpoint pathway upon DNA damage for the efficient repair |