basic FUNCTION
| linking TNFR1 with MAP kinase activation and arachidonic acid release and providing further insight into the mechanisms by which TNF exerts its pleiotropic effects |
|
playing an essential role in calcium mediated exocytosis and neurotransmitter release |
|
sufficient and necessary for cancer cell survival |
|
can play a novel and significant role in regulating cell proliferation, survival and death through alternative mRNA splicing |
|
essential role in protecting cancer cells from TNF-induced apoptosis by specifically activating MAPKs th-rough Grb2 and Sos1/2 recruitment |
|
its ability to resist TRAIL-induced apoptosis is dependent upon its phosphorylation by KT1 |
|
|