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FLASH GENE
Symbol MADD contributors: mct/npt/pgu - updated : 03-04-2013
HGNC name MAP-kinase activating death domain
HGNC id 6766
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain    
Reproductivefemale systemovary   
 male systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines neoplastic cells
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • serine and leucine-rich repeats
  • a RGD cellular adhesion motif
  • a leucine-zipper-like motif
  • a C terminal DEATH domain associating with the DEATH domain of TNFR1 with an alternatively spliced isoform
  • HOMOLOGY
    interspecies homolog to C.elegans AEX3
    intraspecies homolog to Map kinase-activating death domain protein
    Homologene
    FAMILY
  • MAP kinase family
  • MADD family
  • CATEGORY protooncogene , signaling , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • linking TNFR1 with MAP kinase activation and arachidonic acid release and providing further insight into the mechanisms by which TNF exerts its pleiotropic effects
  • playing an essential role in calcium mediated exocytosis and neurotransmitter release
  • sufficient and necessary for cancer cell survival
  • can play a novel and significant role in regulating cell proliferation, survival and death through alternative mRNA splicing
  • essential role in protecting cancer cells from TNF-induced apoptosis by specifically activating MAPKs th-rough Grb2 and Sos1/2 recruitment
  • its ability to resist TRAIL-induced apoptosis is dependent upon its phosphorylation by KT1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TNFR1
  • JNK3
  • is the non-redundant RAB27A GEF in melanocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Alzheimer disease
    tumoral     --over  
    in thyroid tumor tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    . loss of MADD expression does not appear to affect the survival of primary cells, it may be a suitable target to treat cancers either by expressing MADD-specific small interfering RNA or by developing small molecule MADD antagonists
    ANIMAL & CELL MODELS