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FLASH GENE
Symbol HAT1 contributors: npt - updated : 11-02-2002
HGNC name histone acetyltransferase 1
HGNC id 4821
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Digestiveliver   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, S
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • bipartite nuclear localization signal (NLS)
  • secondary structure HAT1 and P46/HAT2 subunits
    HOMOLOGY
    interspecies homolog to Drosophila CG2051
    Homologene
    FAMILY
  • HAT1 family
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • histone actyltransferase 1, catalytic subunit, acetylating soluble (not nucleosomal) newly synthesized histone H4 at Lys5 and Lys12,and H2A at Lys5
  • likely involved in generating modified H4 required for replication-dependent chromatin remodelingand required for DNA repair
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS