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FLASH GENE
Symbol TNFRSF17 contributors: mct - updated : 19-01-2016
HGNC name tumor necrosis factor receptor superfamily, member 17
HGNC id 11913
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
Nervousbrainlimbic systemhippocampus   Mus musculusFetal
Skin/Tegumentskin     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell Homo sapiens
Nervouspyramidal cell Mus musculusFetal
Skin/Tegumentkeratinocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracytoplasmic cysteine-rich pseudorepeats typical for the TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic tail
  • a DEATH domain
  • mono polymer homomer , trimer
    HOMOLOGY
    Homologene
    FAMILY tumor necrosis factor receptor superfamily
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 3 membrane protein
    basic FUNCTION
  • receptor of TNSF13B promoting B-cell survival and playing a role in the regulation of humoral immunity
  • is an inflammation-related TNFSFR member in keratinocytes, of potential importance in the management of inflammatory skin conditions
  • is mostly known for its functional activity in mediating the survival of plasma cells that maintain long-term humoral immunity
  • essential membrane protein for maintaining the survival of plasma cells, identified as a glycoprotein exhibiting complex-type N-glycans at a single N-glycosylation site, asparagine 42
  • importance of N-glycosylation on TNFRSF17 in the regulation of ligand binding and functions of plasma cells
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TNFSF13 binding to TNFRSF17 decreases cell proliferation by inducing G(2)/M cell cycle arrest
  • ELL2 enhances the expression of TNFRSF17, which is important for long-term survival
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in primary Sjogren syndrome
    tumoral   translocation    
    T cell malignant lymphoma with t(4;16)(q26;p13)
    constitutional     --over  
    with TNF, TNFSF13B, TNFSF13 in Behcet disease
    constitutional     --over  
    in inflammatory skin lesions of psoriasis
    tumoral     --over  
    in skin squamous cell carcinomas
    constitutional     --over  
    in systemic lupus erythematosus (SLE)
    Susceptibility to UC (ulcerative colitis) and IBD (inflammatory bowel disease)
    Variant & Polymorphism other
  • haplotypes of the TNFRSF17 polymorphisms might be associated with UC and IBD susceptibility
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    BCMA-/- knockout mice,developing systemic lupus erythematosis