basic FUNCTION
| cell to cell signaling between stromal cells and osteoclast progenitor |
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can act as a soluble factor in the regulation of bone mass  |
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specifically inhibits osteoclastogenesis  |
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playing a role in the vascular system |
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involved in RANKL/RANK signaling |
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regulates dendritic cells survival, monocyte chemotaxis, and B cell development and function by ligating TNF family member receptor activator of NF-kappaB ligand (TNFSF11) |
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acts as an autocrine/paracrine growth factor for vascular smooth muscle cells, which might contribute to the progression of atherosclerotic lesions (Corallini 2009) |
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key factor linking bone formation to resorption during bone remodeling  |
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expression of TNFRSF11B, TNFRSF11A and TNFSF11 genes exert a crucial role in the progression of Femoral head avascular necrosis (AVN), suggesting their roles in mediating bone homeostasis and potential effects on bone destruction  |