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FLASH GENE
Symbol TNFRSF10D contributors: npt/ - updated : 04-09-2007
HGNC name tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
HGNC id 11907
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text abundantly, in liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two extracellular cysteine rich pseudo-repeats typical for TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic tail
  • a truncated DEATH domain
  • mono polymer homomer , trimer
    HOMOLOGY
    intraspecies homolog to TNF
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION
    text type I transmembrane protein (TM1)
    basic FUNCTION
  • apoptosis induced ligand (TRAIL) receptor 4, binding APO2L
  • inducing NFKB and protecting against TRAIL-mediated apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by TP53 inducible
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS