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FLASH GENE
Symbol AURKC contributors: mct - updated : 05-12-2019
HGNC name aurora kinase C
HGNC id 11391
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  predominantly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
cell cycle     cell cycle, checkpoint, G2M
Text at the late pachytene stage
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • catalytic domain
  • central serine/threonine kinase domain
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to Drosophila Aurora
    homolog to yeast S.cerevisiae IPI1
    ortholog to murine Aurkc
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • Aurora subfamily
  • CATEGORY enzyme , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • localized to centrosome from anaphase to cytokinesis
  • co-localized with Aurora B and Survivin (BIRC5) in mitotic cells
  • preferentially expressed during oocyte meiosis
  • basic FUNCTION
  • may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis
  • playing a key role in the organization of the kinetochore
  • being essential for normal chromosome segregation
  • having an involvement in oncogenic signal transduction
  • required for cytokinesis
  • cycle-regulatory serine-threonine kinases implicated in the function of the centrosomes, kinetechores, chromosome dynamics, and cytokinesis
  • having specialized functions in mammalian spermatogenesis
  • support the mitotic progression in the absence of Aurora-B suggesting that the two kinases may have overlapping functions
  • possible role of Aurora-C in telophase and/or cytokinesis
  • implicated in the regulation of mitosis
  • has a role in the later stage of mitosis, when an interaction with TACC1 may be relevant for the correct progression of the cell cycle
  • crucial function of aurora C during the early embryonic cycles
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • chromosomal passenger protein that forms complexes with Aurora-B and inner centromere protein (INCENP), which are known passenger proteins
  • member of the chromosomal passenger complex
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • can also be associated with Aurora B and BIRC5
  • TACC1 is a substrate of AURKC
  • role for HASPIN as a regulator of bipolar spindle assembly by regulating AURKC function at acentriolar microtubule-organizing centers (MTOCs) in oocytes
  • AURKB/AURKC) are activated by binding to the C-terminal domain of INCENP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LHPS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancers and several cancer cell lines
    Susceptibility to primary infertility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS