basic FUNCTION
| cell membrane associated serine protease, involved in processes such as blood coagulation, fibrinolysis, and complement activation |
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having potential roles in development, cell growth, and cell-surface initiation of blood coagulation |
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activating factor VII |
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is required for normal auditory function |
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may play important and specific roles in hearing |
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promotes prostate cancer progression and metastasis and thus represents a potential therapeutic target |
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type II transmembrane trypsin-like serine protease, mediating epithelial integrity and basement membrane (BM) defects |
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HPN and TMPRSS2 colocalize on the cell surface with the secreted serine proteases KLK4 and KLK14, only in membrane protrusions, suggesting that reciprocal proteolytic interactions occur in defined cellular structures that are important during cancer dissemination for cell migration, invasion and survival |