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FLASH GENE
Symbol NCK2 contributors: mct/pgu - updated : 05-04-2016
HGNC name NCK adaptor protein 2
HGNC id 7665
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Reproductivefemale systemplacenta  highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three SH3 domains (signal transduction)
  • a unique SH2 domain wich recognizes a specific phosphotyrosine residue on RTKS or on substrates of RTKS like IRS1, lacking a catalytic domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • transduction adaptator protein 2
  • modulates translation and eIF2alpha signaling in response to ER stress
  • . plays a pivotal role in connecting and integrating signaling networks constituted by transmembrane receptors such as ephrinB and effectors critical for cytoskeletonal dynamics and remodeling
  • NCK1, NCK2 adapters are needed for signaling to Rho GTPases and actin dynamics downstream of the PDGFbeta receptor
  • independent roles and mechanisms of action of NCK1 and NCK2 in dermal fibroblast migration, which is critical for wound healing
  • adaptor protein, involved in signaling pathways mediating proliferation, cytoskeleton organization and integrated stress response
  • effectively influences melanoma phenotype progression
  • NCK1 and NCK2 have non-redundant roles in human T cell activation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EGFR
  • PDGFR
  • WIPF2
  • interaction partner of the active form of NTRK2
  • connection between septins, SOCS7, NCK1/NCK2 signaling, and the DNA damage response
  • connect PDGF-BB signaling to the actin cytoskeleton and cell motility
  • interaction with SORBS1 (implications for a role in cytoskeletal remodelling during differentiation of skeletal muscle cells)
  • SKAP2 interacted with the SH2 domain of non-catalytic region of tyrosine kinase adaptor protein 2 (NCK2) via its N-terminus
  • only NCK2 is required for the SLIT1-induced changes in cortical neuron morphology
  • PAK3 down-regulates synaptic transmission through its interaction with NCK2
  • PLCE1 regulates Rho GTPase activity and cell migration through interacting with NCK2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS