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FLASH GENE
Symbol TPST1 contributors: mct - updated : 03-12-2011
HGNC name tyrosylprotein sulfotransferase 1
HGNC id 12020
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Nervousnerve   highly
Reproductivefemale systemplacenta  highly
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N and C-terminal flanking residues,
  • a transmembrane domain act in targeting and retention of the enzyme to the trans-Golgi compartment
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane glycoproteins
    basic FUNCTION
  • catalyzing tyrosine o-sulfation of proteins
  • acting in targeting and retention of the enzyme to the trans-Golgi compartment
  • transfer the sulfate moiety to proteins predominantly designated for secretion
  • may be functional as homodimer/oligomer in the trans-Golgi compartment
  • involved in photoreceptor outer segment morphogenesis, retinal function and retinal anatomy
  • tyrosine O-sulfation is a post-translational modification catalyzed by two tyrosylprotein sulfotransferases (TPST1 and TPST2) in the trans-Golgi network
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    in shear stress involves tyrosine kinase (Goettsch 2002)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS