basic FUNCTION
| regulating inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4 |
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may be related to carcinogenesis by the modulation of inositol polyphosphates and Ca2+ homeostasis |
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morphological changes induced by ITPKA are mediated by non-enzymatic activities of the protein |
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F-actin binding activity of ITPKA stabilizes and bundles actin filaments and thus increases the levels of cellular F-actin |
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accumulates in dendritic spines and seems to be critically involved in synaptic plasticity |
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dual role in developing neurons, has a morphogenic effect on dendrites, while it appears to play a key role in shaping Ca(2+) transients at mature synapses |
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playing a potential role as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals |
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modulates a structural reorganization of dendritic spines through F-actin remodeling |
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possible function of ITPKA, ITPKB in differentiation of embryonic stem cells |
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expression of ITPKA is essential for lung cancer metastasis |
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actin binding protein essential for metastasis of lung cancer cells and its expression is up-regulated in tumor samples from lung cancer patients |