basic FUNCTION
| possessing an intrinsic histone acetyltransferase activity |
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stimulating gene expression in a hormone dependent fashion by facilitating the assembly of basal transcription factors into a stable preinitiation complex |
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enhancing ligand-dependent and receptor dependent cell-free transcription of chromatin |
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playing a role in potnatal survival and male reproduction |
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controling with NCOA2 energy balance between White and Brown adipose tissues, and involved in the pathogenesis of the obesity |
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essential for the maintenance of bone mass by sex hormones, but not for the catabolic action of glucocorticoid, under both physiological and pathological conditions |
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NCOA1, NCOA2, NCOA3, are not functionally redundant in breast cancer cells because they play gene-specific roles in regulating mRNA and protein expression, and they therefore are likely to make unique contributions to breast tumorigenesis |
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promotes breast cancer invasiveness and metastasis by coactivating ETV4-mediated TWIST1 expression |
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transcriptional coregulator of the glucocorticoid receptor, involved in the sensitivity of CRH regulation by stress-related factors |
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involved in positive and negative regulation of the CRH gene, and an important factor for the adaptive capacity of stress |
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with NCOA3 cooperatively regulate placental morphogenesis and embryo survival |
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NCOA1 and NCOA2 can modulate the expression of the uncoupling protein 3 (UCP3) in an antagonistic manner, and have important metabolic functions in white and brown adipose tissues as well as in the liver |
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regulator in caspase-independent and AIFM1-mediated apoptosis (PMId: 22371500) |
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fetal lungs produce signals to initiate labor when mature and NCOA1/NCOA2-dependent production of SFTPA1B and platelet-activating factor (PAF) is crucial for this process |