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FLASH GENE
Symbol NCOA1 contributors: mct - updated : 07-05-2019
HGNC name nuclear receptor coactivator 1
HGNC id 7668
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Cardiovascularheart    
Reproductivemale systemtestis   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
ReproductiveSertoli cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic helix-loop-helix (HLH) domain juxtaposed to a stretch of 300 AA with the PAS (Per - ARNT - Sim) domain
  • two receptor interacting domains with the LXXLL domain
  • a C terminal histone acetyltransferase domain
  • HOMOLOGY
    Homologene
    FAMILY
  • p160/steroid receptor coactivator (SRC) family
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • possessing an intrinsic histone acetyltransferase activity
  • stimulating gene expression in a hormone dependent fashion by facilitating the assembly of basal transcription factors into a stable preinitiation complex
  • enhancing ligand-dependent and receptor dependent cell-free transcription of chromatin
  • playing a role in potnatal survival and male reproduction
  • controling with NCOA2 energy balance between White and Brown adipose tissues, and involved in the pathogenesis of the obesity
  • essential for the maintenance of bone mass by sex hormones, but not for the catabolic action of glucocorticoid, under both physiological and pathological conditions
  • NCOA1, NCOA2, NCOA3, are not functionally redundant in breast cancer cells because they play gene-specific roles in regulating mRNA and protein expression, and they therefore are likely to make unique contributions to breast tumorigenesis
  • promotes breast cancer invasiveness and metastasis by coactivating ETV4-mediated TWIST1 expression
  • transcriptional coregulator of the glucocorticoid receptor, involved in the sensitivity of CRH regulation by stress-related factors
  • involved in positive and negative regulation of the CRH gene, and an important factor for the adaptive capacity of stress
  • with NCOA3 cooperatively regulate placental morphogenesis and embryo survival
  • NCOA1 and NCOA2 can modulate the expression of the uncoupling protein 3 (UCP3) in an antagonistic manner, and have important metabolic functions in white and brown adipose tissues as well as in the liver
  • regulator in caspase-independent and AIFM1-mediated apoptosis (PMId: 22371500)
  • fetal lungs produce signals to initiate labor when mature and NCOA1/NCOA2-dependent production of SFTPA1B and platelet-activating factor (PAF) is crucial for this process
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CREBBP and PCAF, coactivating PPARG
  • coregulator with EP300 of the STAT3 transcriptional activity
  • NCOA2
  • HRMT1L1
  • interact with distinct sites on the NH2-terminal activation domain of MYOD1
  • interact with and to be an essential co-activator for several members of the STAT (signal transducer and activator of transcription) family, including STAT3, the major signal transducer of IL (interleukin)-6
  • interactions from brain with ESR1 and progestin receptor are dependent on ligand, receptor subtype, and brain region to manifest the pleiotropic functional consequences that underlie steroid-regulated behaviors
  • interacting with NR1H3 (coactivator-binding surface of NR1H3, but not that of RXRA, is critically important for physical and functional interactions with NCOA1)
  • interacts directly with AIFM1 in mitochondria and specifically inhibits caspase-independent and AIFM1-dependent apoptosis (PMId: 22371500)
  • cell & other
    REGULATION
    Other steroid,thypoid hormone dependent
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    in hematological malignancies
    tumoral   translocation    
    t(2;2)(q35;p23), which generates a fusion protein composed of PAX3 and the nuclear receptor coactivator NCOA1, in alveolar rhabdomyosarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    intervention of NCOA1 function may provide new strategies to inhibit breast cancer metastasis
    diabetemetabolic syndrom 
    modulation of the expression and/or activity of NCOA1, NCOA2, represents an attractive way to prevent or treat metabolic disorders
    ANIMAL & CELL MODELS