basic FUNCTION
| developmental protein, dorsalizing factor, dorsoventral axis, acting during gastrulation |
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dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins (Pappano 1998) |
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playing a role as a negative regulator of endochondral ossification |
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inhibitor of bone morphogenetic proteins |
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could participate in regulating BMP activity in normal ovarian surface epithelium physiology |
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with CHRDL2, and BMPER, regulate BMP2 signaling by different recognition mechanisms (Zhang 2007) |
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acts in the pharyngeal region to protect TBX1 expression from inhibition by local BMPs (Choi 2009) |
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modifier for the craniofacial anomalies of TBX1 mutations (existence of a second-site modifier for a specific subset of the phenotypes associated with 22q11 deletion syndrome (Choi 2009) |
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promotes oligodendrogenesis from Subventricular Zone (SVZ) cells in vitro and in vivo and regulates oligodendrogenesis after demyelination (Jablonska 2010) |