basic FUNCTION
| participating in the transduction of signals from Ras to Rac by regulating Rac-specific guanine nucleotide exchange factor (GEF) activities |
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playing an essentiel role in modulating WASF2 effector functions |
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implicated in growth-factor-mediated regulation of the small GTPases p21Ras and Rac |
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promotes ABL-mediated PIK3AP1 phosphorylation, suggesting that ABI11 in general coordinates kinase-substrate interactions |
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adaptor protein involved in actin reorganization and lamellipodia formation |
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plays an important role in the spread of breast cancer and that this role may be mediated via the phosphatidylinositol 3-kinase pathway |
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plays critical roles both in the pathogenesis of BCR-Abl-induced leukemia and in the spread of several solid tumors |
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key regulator of actin polymerization/depolymerization |
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role in the regulation of morphogenesis |
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promotes the ABL-mediated phosphorylation of ENAH by binding both ABL and ENAH |
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plays a critical function in actin cytoskeleton dynamics through participation in the WASF2 complex |