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FLASH GENE
Symbol AQP7 contributors: mct/npt - updated : 29-09-2007
HGNC name aquaporin 7
HGNC id 640
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Nervousnervecranial nerve  highly
Reproductivefemale systembreastmammary gland highly
 male systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six transmembrane segments (6TM)
  • intracellular N and C termini
  • HOMOLOGY
    Homologene
    FAMILY
  • MIP family
  • aquaglyceroporin family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • aquaglyceroporins, that transport glycerol
  • and small solutes in addition to water (Sorani 2008)
  • water channel forming integral protein
  • putatively involved in the formation of late spermatids
  • may be responsible for the increase of plasma glycerol during exercise, and for glycerol permeability and other small solutes
  • acting as a glycerol gateway molecule in adipocytes for the efficient release of glycerol and protecting against obesity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by insulin via insulin response element of the promoter
    Other adipose tissue expression is regulated by fasting-refeeding, insulin, dexamethasone, TNF, isoproterenol, and peroxisome proliferator-activated receptor PPARA, PPARG
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in severely obese women
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target aquaporins appear to be important for the development of novel drug therapies for Meniere's disease and related disorders (Takeda 2009)
    ANIMAL & CELL MODELS
    Aqp7 disruption in mouse associated with obesity