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FLASH GENE
Symbol PLA2G6 contributors: mct - updated : 15-02-2012
HGNC name phospholipase A2, group VI (cytosolic, calcium-independent)
HGNC id 9039
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Lymphoid/Immunethymus   highly
Nervousbrain    
Reproductivemale systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a lipase consensus sequence (GTSTG)
  • seven ankyrin repeats
  • multiple alternatively splicing forms with distinct tissue distribution and cellular localization
  • patatin domain
  • conjugated Other
    HOMOLOGY
    Homologene
    FAMILY
  • phospholipase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • participating in Fas mediated apoptosis
  • involved in the remodeling of membranes allowing arachidonic acid to be placed in the proper position in phospholipids for stimulated release
  • possible role for PLA2G6 in neuronal proliferation throughout the developing brain and in maturing neurons in the cortical plate and hindbrain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • pathway leading to CYBB activation in which PLA2G6-regulated MAPK14 activity is a key regulator of S100A8/A9 translocation via S100A9 phosphorylation
  • a component
  • oligomeric complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NBIA2 , INAD1 , PARK14
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    results in excessive exocytosis through increased oxidative damage (or failure to repair such damage) and defects in mitochondrial function (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neuromuscularmyopathy 
    inhibition of iPLA(2) and lysophospholipid production may be of interest to reduce Ca(2+) entry and subsequent degeneration of dystrophic muscle
    ANIMAL & CELL MODELS