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FLASH GENE
Symbol CDC7 contributors: mct - updated : 04-01-2015
HGNC name CDC7 cell division cycle 7 (S. cerevisiae)
HGNC id 1745
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, interphase, S
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a protein kinase domain
  • C-terminal 143-amino acid polypeptide (432-574) containing DAM-1 and DAM-2 can interact with DBF4
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae cdc7p
    homolog to murine Cdc7 (81.4pc)
    intraspecies homolog to cell division cycle CDC7 related kinase
    Homologene
    FAMILY
  • protein kinase superfamily
  • ser/thr protein kinase family
  • CDC7 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text nuclear import is mediated directly by importin-beta
    basic FUNCTION
  • serine/threonine kinase, putative regulator of G1/S phase transition and so cell cycle progression
  • playing an essential role in meiotic process
  • activating the initiation of DNA replication by modulating MCM functions (phosphorylating, MCM4, MCM2 proteins)
  • involved in initiation and progression of DNA replication
  • CDC7-DBF4 is a conserved protein kinase required for the initiation of DNA replication
  • CDC7-DBF4 prevents inappropriate exit from mitosis by inhibiting Polo kinase and functions in the spindle position checkpoint
  • phosphorylates the minichromosome maintenance protein 2 (MCM2), a component of the DNA replicative helicase needed for genome duplication
  • play a key role in the regulation of initiation at each replication origin
  • is one of the factors mediating both the proliferation and Smooth muscle cell (SMC) differentiation
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell cycle, progression
    nucleotide, replication
    PHYSIOLOGICAL PROCESS
    text
  • regulator of DNA replication
  • PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • interacting with CRM1, leading to the translocation of CDC7 from nucleus to cytoplasm
  • interacts with and phosphorylates Claspin (CLSPN) (CDC7 is potentially required for activation of the ATR-CHEK1 checkpoint pathway through regulation of Claspin)
  • RAD18 is a substrate of the essential protein kinase CDC7
  • CDC7-DBF4 interaction with CDC5
  • bipartite interaction between CDC7 and DBF4 subunits facilitates ATP binding and substrate recognition by the CDC7 kinase
  • SMAD3 is required for CDC7 function in inducing SMC promoter activities and marker gene expression
  • role for CDC7 -mediated phosphorylation of MCM2 in the response to replicative stress, including some forms of DNA damage
  • CDC7-bound PGK1 converts ADP to ATP, thereby abrogating the inhibitory effect of ADP on CDC7-ASK activity, promoting the recruitment of DNA helicase to replication origins, DNA replication, cell proliferation, and brain tumorigenesis
  • cell & other
    REGULATION
    Other may be down-regulated by the binding of CRM1, masking its kinase domain
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpression of the protein may be associated with neoplastic transformation for some tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    inhibition of CDC7 kinase activity in cancer cells restricts DNA replication and induces apoptotic cell death by an unprecedented molecular mechanism of action
    cancerreproductiveovary
    potent anticancer target in epithelial ovarian carcinoma
    ANIMAL & CELL MODELS