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FLASH GENE
Symbol CYP2A13 contributors: - updated : 28-11-2005
HGNC name cytochrome P450, family 2, subfamily A, polypeptide 13
HGNC id 2608
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
reproductiverespiratory tract    
Respiratorylung    
 respiratory tracttrachea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium  
Epithelialbarrier/lininguroepithelium  
Epithelialsecretoryglandularexocrine 
Membranesensory   
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer monomer
HOMOLOGY
Homologene
FAMILY
  • cytochrome P450 subfamily IIA
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • acting as a monoxygenase oxygenerating major tobacco-specific carcinogens
  • activating the nicotine-derived procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) into DNA-altering compounds
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism drug
    signaling
    oxidative metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein flavoprotein P450 oxidoreductase (POR)
    cell & other
    REGULATION
    induced by phenobarbital
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to lung cancer
    Variant & Polymorphism other CYP2A13*7 allele increasing the risk of lung cancer
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS