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FLASH GENE
Symbol SYNGR1 contributors: - updated : 28-08-2007
HGNC name synaptogyrin 1
HGNC id 11498
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain    
 nervecranial nerve  highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transmembrane segments with cytoplasmic N and C termini
  • two conserved cysteine residues between TM1 and TM2
  • a MARVEL domain
  • HOMOLOGY
    interspecies homolog to murine syngr1
    Homologene
    FAMILY synaptogyrin family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • vesicle protein of synaptic vesicles
  • associated with presynaptic vesicles in neuronal cells
  • basic FUNCTION
  • involved in synaptic plasticity without being required for synaptic transmission
  • involved in presynaptic pathways, and may be in the pathogenesis of schizophrenia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia (SCZ) and bipolar disorder
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS