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FLASH GENE
Symbol MVK contributors: mct - updated : 20-06-2017
HGNC name mevalonate kinase (mevalonic aciduria)
HGNC id 7530
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Endocrinepancreas    
Lymphoid/Immunespleen    
Nervousbrain    
Reproductivefemale systemuteruscervix  
 male systemprostate   
Skin/Tegumentskin    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
N terminal putative ATP binding aminoacid sequence
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Mvk
Homologene
FAMILY GHMP kinase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic
text
basic FUNCTION
  • catalyzing an early step in the mevalonate pathway (conversion of murelonate into 5-phosphomevalonate) for the synthesis of isoprenoids and cholesterol
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
  • a structural constituent of membranes and precursor for bile acids and steroid hormones
  • homodimeric enzyme
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MVK is a LH receptor mRNA binding protein regulating LH receptor activity in ovary
  • binds to the coding region of LHCGR mRNA, suppresses its translation, and the resulting ribonucleoprotein complex is targeted for degradation
  • by inhibiting EIF5A hypusination, FSH reduces the expression of MVK that increases LHCGR mRNA expression by abrogating the inhibitory action of MVK
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MVKD , HIDS , POROK3
    related resource INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS