basic FUNCTION
| central player in mediating cytoskeletal reorganization and are epistatically positioned in a pathway downstream of Rho activation |
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directing nucleation and elongation of new actin filaments using its conserved formin-homology-2 (FH2) domain |
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DIAPH1 and DAAM1 are platelet actin assembly factors having distinct efficiencies, and they are directly regulated by Rho GTPases |
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regulates endothelial cell growth through microtubules stabilization in a cell type-selective manner |
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may be playing an unique role in endothelial cells not shared with other similar cell types |
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plays a key role in centrosome polarity |
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plays an important role in regulating the actin cytoskeleton via mediation of linear actin assembly |
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crucial role in regulating the actin cytoskeleton and tissue morphogenesis, and in heart morphogenesis |
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participates in noncanonical Wnt signaling during gastrulation |
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DIAPH2, DAAM1, FMNL1, and FMNL2 were found to be required for myofibrillogenesis, non-redundantly |
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DAAM1 and DAAM2 nucleate actin and mediate Wnt-induced cytoskeletal changes |