basic FUNCTION
| COBL is an actin nucleator controlling neuronal morphology and development |
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SPIRE1, SPIRE2, and COBL can synergize with other actin regulators |
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is a novel WH2 domain-based actin nucleator |
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COBL and PACSIN1 work together in dendritic arbor development |
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COBL and SPIRE1, SPIRE2 display different functions by selecting different sets of the multifunctional properties of WH2 domains |
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the formation of distinct types of ciliary structures relies on membrane topology-modulating mechanisms that are based on F-BAR domain functions and on complex formation of PACSIN1 with the actin nucleator COBL |
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ciliated sensory hair cell formation and function require the F-BAR protein PACSIN1 and the WH2 domain-based actin nucleator COBL |
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F-actin-anchored COBL/DBNL complexes seem crucial for neuromorphogenesis processes, particularly for the postnatal arborization of Purkinje cells representing the source for all motor coordination in the cerebellar cortex |
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is a regulator of actin dynamics in neural development and ciliogenesis |
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plays some role in early arborization of neurons and nucleates actin by a mechanism that requires a combination of all three of its actin monomer-binding WH2 domains |
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is a multifunctional WASP-Homology 2 (WH2) domain-containing protein implicated in a wide variety of cellular functions ranging from dendritic arborization in neurons to the assembly of microvilli on the surface of transporting epithelial cell |
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COBL induces the formation of dynamic linear actin structures throughout the cytosol, and contributes to the assembly of actin-based structures such as epithelial microvilli |
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actin nucleator COBL is critical for neuronal morphogenesis |
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COBL-dependent planar cell polarity maintenance and refinement processes seem critical for hearing |
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actin nucleator COBL is an important effector in postnatal refinement and maintenance of planar cell polarity |