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FLASH GENE
Symbol COBL contributors: mct - updated : 25-09-2018
HGNC name cordon-bleu WH2 repeat protein
HGNC id 22199
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal COBL domain, binding several BAR-containing proteins, including SNX9, PACSIN 2/syndapin 2, and ASAP1
  • three C-terminal WH2 domains, WH2 repeats that confer multifunctional regulation of actin dynamics, which makes COBL a « dynamizer » of actin assembly
  • HOMOLOGY
    interspecies homolog to murine cordon bleu
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nuclear envelope
    text
  • has a very specific localization in epithelial cells at the basal region of microvilli, a localization unlikely to be involved in actin nucleation
  • localizes to the base of brush border (BB) microvilli via a mechanism that requires its proline-rich N-terminus
  • basic FUNCTION
  • COBL is an actin nucleator controlling neuronal morphology and development
  • SPIRE1, SPIRE2, and COBL can synergize with other actin regulators
  • is a novel WH2 domain-based actin nucleator
  • COBL and PACSIN1 work together in dendritic arbor development
  • COBL and SPIRE1, SPIRE2 display different functions by selecting different sets of the multifunctional properties of WH2 domains
  • the formation of distinct types of ciliary structures relies on membrane topology-modulating mechanisms that are based on F-BAR domain functions and on complex formation of PACSIN1 with the actin nucleator COBL
  • ciliated sensory hair cell formation and function require the F-BAR protein PACSIN1 and the WH2 domain-based actin nucleator COBL
  • F-actin-anchored COBL/DBNL complexes seem crucial for neuromorphogenesis processes, particularly for the postnatal arborization of Purkinje cells representing the source for all motor coordination in the cerebellar cortex
  • is a regulator of actin dynamics in neural development and ciliogenesis
  • plays some role in early arborization of neurons and nucleates actin by a mechanism that requires a combination of all three of its actin monomer-binding WH2 domains
  • is a multifunctional WASP-Homology 2 (WH2) domain-containing protein implicated in a wide variety of cellular functions ranging from dendritic arborization in neurons to the assembly of microvilli on the surface of transporting epithelial cell
  • COBL induces the formation of dynamic linear actin structures throughout the cytosol, and contributes to the assembly of actin-based structures such as epithelial microvilli
  • actin nucleator COBL is critical for neuronal morphogenesis
  • COBL-dependent planar cell polarity maintenance and refinement processes seem critical for hearing
  • actin nucleator COBL is an important effector in postnatal refinement and maintenance of planar cell polarity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • COBL-mediated dendritic branch induction in hippocampal neurons critically relied on DBNL
  • COBL acts downstream of the F-BAR protein PACSIN2, which drives COBL targeting to the apical domain
  • COBL-mediated dendritic arborization required PRMT2, complex formation with PRMT2, and PRMT2 catalytic activity
  • cell & other
    REGULATION
    Other is regulated by Ca2+ and multiple, direct associations of the Ca2+ sensor Calmodulin (CaM)
    is controlled by arginine methylation, and COBL methylation is key for COBL actin binding
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS