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FLASH GENE

Symbol

RUSC2

contributors: mct - updated : 11-01-2017

HGNC name	RUN and SH3 domain containing 2
HGNC id	23625

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Homo sapiens Skin/Tegument skin

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a minimal functional RAB35-binding site of RUSC2 (AA 982-1199), the RBD35 (Rab-binding domain specific for RAB35)
	a RUN domain
	a C-terminal SH3 domain

HOMOLOGY

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,vesicle

basic FUNCTION	might function as a link between the targeting of ER derived vesicles, triggered by the RAB1 GTPase and a signaling pathway regulated by molecules containing SH3 and/or poly-proline regions
	RUSC2 participates in EGFR signaling and regulates lung cancer progression
	RUSC2 inhibits HH signaling, by preventing signaling-induced dissociation of the SUFU-GLI complexes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

RUSC1 and RUSC2 are novel components of the vertebrate HH pathway

a component

INTERACTION

DNA

RNA

small molecule

protein	is a novel RAB1A, RAB1B-interacting protein
	GIT2 control cell polarization and direction dependent on the regulation of Golgi through RUSC2
	RUSC2 interacts with SHD of GIT2 in various lung cancer cells, and stabilizes GIT2
	RUSC1 and RUSC2 interact with SUFU and restrict the response of cells to HH signaling

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MRMC

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer lung   may be a new therapeutic target against lung cancer metastasis

ANIMAL & CELL MODELS