Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KIF3B contributors: mct/npt/pgu - updated : 28-09-2017
HGNC name kinesin family member 3B
HGNC id 6320
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunelymph node   highly
Nervousbrain    
Urinarykidney   highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor Homo sapiens
Visualrod photoreceptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • globular N terminal domain
  • a central motor domain with an ATP binding site
  • a coiled-coil domain
  • a C terminal alpha helical tail, responsible for heterodimerization
  • HOMOLOGY
    interspecies homolog to murine kinesin KIF3B
    homolog to C.elegans y50d7a.6
    Homologene
    FAMILY
  • kinesin family 3
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text cilia
    basic FUNCTION
  • basic ciliary activity-putatively involved in the nodal flow supposed to break symetry
  • kinesin-2 complex (KIF3A, KIF3B) plays an important role not only in interphase but also in mitosis
  • PKP4 and ECT2 are transported via distinct motors, identifying a novel pathway implicating KIF3B in the regulation of actin organization during cytokinesis
  • heterotrimeric motor protein that facilitates fast anterograde translocation of membranous organelles
  • involved in the trafficking of SLC4A1 to the plasma membrane of kidney alpha-intercalated cells
  • playing a role in SLC4A1 trafficking to the plasma membrane
  • KIF3B mutant photoreceptor cilia differentiate with a delay, suggesting that KIF3C, although redundant with KIF3B at later stages of differentiation, is not active early in photoreceptor ciliogenesis
  • KIF3A, KIF3B (KIF3AB) is an N-terminal processive kinesin-2 family member best known for its role in intraflagellar transport
  • the kinesin-2 family motor KIF3A/KIF3B works together with dynein to bidirectionally transport intraflagellar particles, melanosomes, and neuronal vesicles
  • KIF3A, KIF3B, KIF3C is classified as a heterotrimeric kinesin-2 that is best known for organelle transport in neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text determination of left-right asymmetry, intracellular organelle transport
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • heterodimere of KIF3A and KIF3P
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CSPG6
  • associating with PKHD1 and PKD2 (mediates the regulation of PKD2 channel function by PKHD1)
  • interaction with ARHGEF10 (KIF3B may modulate the ARHGEF10-RhoA pathway through the binding to ARHGEF10)
  • CLCN5 interacts with kinesin family member 3B (C-terminus of CLCN5 and the coiled-coil and globular domains of KIF3B were shown to interact) (KIF3B)
  • SLC4A1 interacts with KIF3B in the kidney tissue (a dileucine motif at the C-terminal SLC4A1 contributes to its interaction with KIF3B)
  • RNF33 most likely interacted with KIF3A-KIF3B independent of the adaptor kinesin-associated protein KIFAP3
  • GLI1 interactions with KIF3A-KIF3B-KIFAP3 complexes are essential for proper GLI1 transcriptional activity
  • PKP4 directly interacts with the KIF3/subunit KIF3B, and also interacts with the kinesin cargo adaptor protein KIFAP3 acting as a stabilizing linker between KIF3B and its KIFAP3 cargo binding entity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RP89
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma (HCC)tumor tissues and proliferating HCC cells, and an increased KIF3B expression was associated with poor overall survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    murine Kif3b-/- have randomized situs