SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic
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text
| SAR1A activity required to maintain SEC16A localization at discrete locations on the ER membrane (perhaps by preventing its dissociation) |
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mostly cytosolic |
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remains associated with ER exit sites throughout mitosis |
basic FUNCTION
| defining endoplasmic reticulum exit sites (ERES) by SAR1A-GTP-dependent assembly on the ER membrane |
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being required for secretory cargo trafic from the endoplasmic reticulum to the Golgi apparatus |
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required for normal transitional endoplasmic reticulum (tER) organization |
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acting as a phosphoinositide 5-phosphatase |
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acts as a platform for COPII assembly at ER-exit sites |
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unlike all other COPII components, which are cytosolic during metaphase, remains associated with ER exit sites throughout mitosis, and thereby could provide a template for the rapid assembly of functional export domains in anaphase |
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SEC16A and RAB10 promote insulin-stimulated mobilization of SLC2A4 from a perinuclear recycling endosome/TGN compartment |